Welcome to ARIES - Alnylam’s Global Medical Research Submission Portal!

This website will enable you to submit your Investigator Initiated Study proposal for review, track the progress of your existing proposal, and report on ongoing studies.

Investigator initiated proposals are submitted to Alnylam through ARIES, the online submission portal. Our review process and considerations for your proposal are outlined below. For detailed information on how to prepare your proposal or submission requirements, please reach out to your local field medical Alnylam contact or contact medicalresearch@alnylam.com for more information.




Application & Review

Step 1:     Input concept into Medical Research Portal (ARIES)

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  • Review concept
  • Communicate decision to approve/decline/requires more information

Decision Made

Step 2:     Full Protocol/Detailed Budget submission in Medical Research Portal (ARIES)

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  • Review Protocol/Detailed Budget
  • Communicate decision to initiate research agreement contract or decline

Study Execution and Reporting

Contracting Initiated

Step 3:     Contract negotiations between Institution and Alnylam Legal

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  • Approve final budget and suggested milestone payments
  • Execute final contract

Study is Active

Step 4:  Provide study/enrollment updates, submit Interim and/or Final Reports into Medical Research portal (ARIES) per contract requirements

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  • Monitor progress of study
  • Review invoices for milestone payments
  • Review submitted Final Study Report and/or draft manuscript, poster or abstract (courtesy review)

Study Completed/Closed Out